mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor alpha serine 167 phosphorylation.

@article{Yamnik2010mTORS6K1AM,
  title={mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor alpha serine 167 phosphorylation.},
  author={Rachel L. Yamnik and Marina K. Holz},
  journal={FEBS letters},
  year={2010},
  volume={584 1},
  pages={124-8}
}
Resistance to anti-estrogen therapy is a major clinical concern in treatment of breast cancer. Estrogen-independent phosphorylation of estrogen receptor alpha, specifically on Ser167, is one of the contributing causes to development of resistance, and a prognostic marker for the disease. Here, we dissect the signaling pathways responsible for Ser167… CONTINUE READING