mTOR, linking metabolism and immunity.

  title={mTOR, linking metabolism and immunity.},
  author={Xiaojin Xu and Lilin Ye and Koichi Araki and Rafi Ahmed},
  journal={Seminars in immunology},
  volume={24 6},
mTOR is an evolutionarily conserved serine/threonine kinase that plays a critical role in cell growth and metabolism by sensing different environmental cues. There is a growing appreciation of mTOR in immunology for its role in integrating diverse signals from the immune microenvironment and coordinating the functions of immune cells and their metabolism. In CD8 T cells, mTOR has shown to influence cellular commitment to effector versus memory programming; in CD4 T cells, mTOR integrates… CONTINUE READING

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