mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat.

@article{Chotechuang2009mTORAA,
  title={mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat.},
  author={N. Chotechuang and D. Azzout-Marniche and C. Bos and C. Chaumontet and N. Gausser{\`e}s and T. Steiler and C. Gaudichon and D. Tom{\'e}},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2009},
  volume={297 6},
  pages={
          E1313-23
        }
}
Three transduction pathways are involved in amino acid (AA) sensing in liver: mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), and general control nondepressible kinase 2 (GCN2). However, no study has investigated the involvement of these signaling pathways in hepatic AA sensing. To address the question of liver AA sensing and signaling in response to a high-protein (HP) dietary supply, we investigated the changes in the phosphorylation state of hepatic mTOR (p-mTOR… Expand
mTORC1 signaling in energy balance and metabolic disease
Liver GCN2 controls hepatic FGF21 secretion and modulates whole-body postprandial oxidation profile under a low-protein diet.
[AMP-activated protein kinase (AMPK) as therapeutic target].
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 63 REFERENCES
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.
Glucagon Represses Signaling through the Mammalian Target of Rapamycin in Rat Liver by Activating AMP-activated Protein Kinase*
The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.
Activation of AMP‐activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders
Liver glyconeogenesis: a pathway to cope with postprandial amino acid excess in high-protein fed rats?
Thr2446 Is a Novel Mammalian Target of Rapamycin (mTOR) Phosphorylation Site Regulated by Nutrient Status*
Activation of AMP-Activated Protein Kinase Leads to the Phosphorylation of Elongation Factor 2 and an Inhibition of Protein Synthesis
...
1
2
3
4
5
...