mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat.

@article{Chotechuang2009mTORAA,
  title={mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat.},
  author={N. Chotechuang and D. Azzout-Marniche and C. Bos and C. Chaumontet and N. Gausser{\`e}s and T. Steiler and C. Gaudichon and D. Tom{\'e}},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2009},
  volume={297 6},
  pages={
          E1313-23
        }
}
Three transduction pathways are involved in amino acid (AA) sensing in liver: mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), and general control nondepressible kinase 2 (GCN2). However, no study has investigated the involvement of these signaling pathways in hepatic AA sensing. To address the question of liver AA sensing and signaling in response to a high-protein (HP) dietary supply, we investigated the changes in the phosphorylation state of hepatic mTOR (p-mTOR… Expand
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