mTERF2 regulates oxidative phosphorylation by modulating mtDNA transcription.

@article{Wenz2009mTERF2RO,
  title={mTERF2 regulates oxidative phosphorylation by modulating mtDNA transcription.},
  author={Tina Wenz and Corneliu C. Luca and Alessandra Torraco and Carlos T Moraes},
  journal={Cell metabolism},
  year={2009},
  volume={9 6},
  pages={499-511}
}
Regulation of mitochondrial protein expression is crucial for the function of the oxidative phosphorylation (OXPHOS) system. Although the basal machinery for mitochondrial transcription is known, the regulatory mechanisms are not completely understood. Here, we characterized mTERF2, a mitochondria-localized homolog of the mitochondrial transcription termination factor mTERF1. We show that inactivation of mTERF2 in the mouse results in a myopathy and memory deficits associated with decreased… CONTINUE READING
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