mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent

@article{Sajid2021mRNAVI,
  title={mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent},
  author={Andaleeb Sajid and Jaqueline Matias and Gunjan Arora and Cheyne Kurokawa and Kathleen Deponte and Xiaotian Tang and Geoffrey E. Lynn and Ming-Jie Wu and Utpal Pal and Norma Olivares Strank and Norbert Pardi and Sukanya Narasimhan and Drew Weissman and Erol Fikrig},
  journal={Science Translational Medicine},
  year={2021},
  volume={13}
}
Description An Ixodes scapularis saliva mRNA vaccine induces tick resistance and prevents Borrelia burgdorferi infection in guinea pigs. An mRNA vaccine for ticks Repeated exposures to the black-legged tick, Ixodes scapularis, can lead to acquired resistance against ticks or “tick immunity.” To bypass the need for repeated exposures while still generating tick resistance, Sajid et al. developed an mRNA vaccine that encoded for 19 I. scapularis salivary proteins (19ISP). Guinea pigs vaccinated… 

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