mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans

@article{Cal1998mRNASM,
  title={mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans},
  author={Benedetto Cal{\`i} and Philip Anderson},
  journal={Molecular and General Genetics MGG},
  year={1998},
  volume={260},
  pages={176-184}
}
Nonsense mutant mRNAs are unstable in all eucaryotes tested, a phenomenon termed nonsense-mediated mRNA decay (NMD) or mRNA surveillance. Functions of the seven smg genes are required for mRNA surveillance in Caenorhabditis elegans. In Smg(+) genetic backgrounds, nonsense-mutant mRNAs are unstable, while in Smg(−) backgrounds such mRNAs are stable. Previous work has demonstrated that the elevated level of nonsense-mutant mRNAs in Smg(−) animals can influence the phenotypic effects of… CONTINUE READING

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