mRNA splicing in trypanosomes.

  title={mRNA splicing in trypanosomes.},
  author={Christian Preusser and Nicolas Ja{\'e} and Albrecht Bindereif},
  journal={International journal of medical microbiology : IJMM},
  volume={302 4-5},
The parasitic unicellular trypanosomatids are responsible for several fatal diseases in humans and livestock. Regarding their biochemistry and molecular biology, they possess a multitude of special features such as polycistronic transcription of protein-coding genes. The resulting long primary transcripts need to be processed by coupled trans-splicing and polyadenylation reactions, thereby generating mature mRNAs. Catalyzed by a large ribonucleoprotein complex termed the spliceosome, trans… CONTINUE READING

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