mRNA secondary structure optimization using a correlated stem–loop prediction

@inproceedings{Gaspar2016mRNASS,
  title={mRNA secondary structure optimization using a correlated stem–loop prediction},
  author={Paulo Gaspar and Gabriela R. Moura and Manuel A. S. Santos and Jos{\'e} Lu{\'i}s Oliveira},
  booktitle={Nucleic acids research},
  year={2016}
}
  • Paulo Gaspar, Gabriela R. Moura, +1 author José Luís Oliveira
  • Published in Nucleic acids research 2016
  • Medicine
  • Secondary structure of messenger RNA plays an important role in the bio-synthesis of proteins. Its negative impact on translation can reduce the yield of protein by slowing or blocking the initiation and movement of ribosomes along the mRNA, becoming a major factor in the regulation of gene expression. Several algorithms can predict the formation of secondary structures by calculating the minimum free energy of RNA sequences, or perform the inverse process of obtaining an RNA sequence for a… CONTINUE READING

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