mRNA profiling reveals significant transcriptional differences between a multipotent progenitor and its differentiated sister

@article{Mathies2019mRNAPR,
  title={mRNA profiling reveals significant transcriptional differences between a multipotent progenitor and its differentiated sister},
  author={Laura D. Mathies and Surjyendu Ray and Kayla Lopez-Alvillar and Michelle N. Arbeitman and Andrew G. Davies and Jill C Bettinger},
  journal={BMC Genomics},
  year={2019},
  volume={20}
}
BackgroundThe two Caenorhabditis elegans somatic gonadal precursors (SGPs) are multipotent progenitors that generate all somatic tissues of the adult reproductive system. The sister cells of the SGPs are two head mesodermal cells (hmcs); one hmc dies by programmed cell death and the other terminally differentiates. Thus, a single cell division gives rise to one multipotent progenitor and one differentiated cell with identical lineage histories. We compared the transcriptomes of SGPs and hmcs in… 
A Modified TurboID Approach Identifies Tissue-Specific Centriolar Components In C. elegans
TLDR
The recently developed variant TurboID successfully probes the interactomes of both stably associated (SPD-5) and dynamically localized (PLK-1) centrosomal components and an indirect proximity labeling method employing a GFP nanobody-TurboID fusion, which allows the identification of protein interactors in a tissue-specific manner in the context of the whole animal.
A modified TurboID approach identifies tissue-specific centriolar components in C. elegans
TLDR
The recently developed variant TurboID successfully probes the interactomes of both stably associated (SPD-5) and dynamically localized (PLK-1) centrosomal components and an indirect proximity labeling method employing a GFP nanobody-TurboID fusion, which allows the identification of protein interactors in a tissue-specific manner in the context of the whole animal.
The avermectin/milbemycin receptors of parasitic nematodes.

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