mRNA expression signature of Gleason grade predicts lethal prostate cancer.

@article{Penney2011mRNAES,
  title={mRNA expression signature of Gleason grade predicts lethal prostate cancer.},
  author={Kathryn L. Penney and Jennifer A. Sinnott and Katja Fall and Yudi Pawitan and Yujin Hoshida and Peter Kraft and Jennifer Rider Stark and Michelangelo Fiorentino and Sven Perner and S. James Finn and Stefano Calza and Richard Flavin and Matthew L. Freedman and Sunita R. Setlur and Howard D Sesso and S. Andersson and Neil R.W. Martin and Philip W. Kantoff and J. Johansson and Hans-Olov Adami and Mark A. Rubin and Massimo F. Loda and Todd R. Golub and Ove Andr{\'e}n and MeirJ. Stampfer and Lorelei A. Mucci},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 17},
  pages={
          2391-6
        }
}
PURPOSE Prostate-specific antigen screening has led to enormous overtreatment of prostate cancer because of the inability to distinguish potentially lethal disease at diagnosis. We reasoned that by identifying an mRNA signature of Gleason grade, the best predictor of prognosis, we could improve prediction of lethal disease among men with moderate Gleason 7 tumors, the most common grade, and the most indeterminate in terms of prognosis. PATIENTS AND METHODS Using the complementary DNA-mediated… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 65 CITATIONS, ESTIMATED 45% COVERAGE

FILTER CITATIONS BY YEAR

2011
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations

  • Averaged 5 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES

Gleason score and lethal prostate cancer: does 3 + 4 = 4 + 3?

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2009
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…