mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer

@article{Cheng2009mRNAEP,
  title={mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer},
  author={Chao Cheng and Xu Ping Fu and Pedro Mestre Ferreira Alves and Mark B Gerstein},
  journal={Genome Biology},
  year={2009},
  volume={10},
  pages={R90 - R90}
}
Recent studies have shown that the regulatory effect of microRNAs can be investigated by examining expression changes of their target genes. Given this, it is useful to define an overall metric of regulatory effect for a specific microRNA and see how this changes across different conditions. Here, we define a regulatory effect score (RE-score) to measure the inhibitory effect of a microRNA in a sample, essentially the average difference in expression of its targets versus non-targets. Then we… CONTINUE READING

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