mRNA expression profiles for Escherichia coli ingested by normal and phagocyte oxidase-deficient human neutrophils.

@article{Staudinger2002mRNAEP,
  title={mRNA expression profiles for Escherichia coli ingested by normal and phagocyte oxidase-deficient human neutrophils.},
  author={Benjamin J Staudinger and Michele A Oberdoerster and Patrick J Lewis and Henry Rosen},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={110 8},
  pages={1151-63}
}
To gain a better understanding of bacterial responses to complex and hostile environments generated within the neutrophil phagosome, we estimated mRNA abundance, using genomic arrays, in Escherichia coli cells ingested by normal and phagocyte oxidase-deficient human neutrophils. Genes regulated by the oxidant sensing transcription factor OxyR were among those strongly induced upon phagocytosis by normal, but not oxidase-deficient, neutrophils. Several genes related to nitrogen metabolism… CONTINUE READING

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