mRNA expression of glomerular basement membrane proteins and TGF-beta1 in human membranous nephropathy.

@article{Kim1999mRNAEO,
  title={mRNA expression of glomerular basement membrane proteins and TGF-beta1 in human membranous nephropathy.},
  author={Tae Su Kim and Ji Yun Kim and Hye Kyung Hong and H. S. Lee},
  journal={The Journal of pathology},
  year={1999},
  volume={189 3},
  pages={425-30}
}
Immunogold densities for the 'classical' and 'novel' alpha chains of type IV collagen, laminin, and fibronectin are increased in the spikes in human membranous nephropathy (MN). To investigate the molecular mechanisms which underlie these changes in glomerular basement membrane (GBM) components, alpha1(IV) collagen, alpha4(IV) collagen, S-laminin, fibronectin, transforming growth factor (TGF)-beta1 and TGF-beta2 mRNA expression was examined in 12 renal biopsy specimens with MN and six renal… CONTINUE READING

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