mRNA display: ligand discovery, interaction analysis and beyond.

  title={mRNA display: ligand discovery, interaction analysis and beyond.},
  author={Terry T. Takahashi and Ryan J. Austin and Richard W Roberts},
  journal={Trends in biochemical sciences},
  volume={28 3},
In vitro peptide and protein selection using mRNA display enables the discovery and directed evolution of new molecules from combinatorial libraries. These selected molecules can serve as tools to control and understand biological processes, enhance our understanding of molecular interactions and potentially treat disease in therapeutic applications. In mRNA display, mRNA molecules are covalently attached to the peptide or protein they encode. These mRNA-protein fusions enable in vitro… CONTINUE READING