mRNA deadenylation by Pan2-Pan3.

  title={mRNA deadenylation by Pan2-Pan3.},
  author={Jana Wolf and Lori A Passmore},
  journal={Biochemical Society transactions},
  volume={42 1},
Poly(A) tails are important regulators of mRNA stability and translational efficiency. Cytoplasmic removal of poly(A) tails by 3'→5' exonucleases (deadenylation) is the rate-limiting step in mRNA degradation. Two exonuclease complexes contribute the majority of the deadenylation activity in eukaryotes: Ccr4-Not and Pan2-Pan3. These can be specifically recruited to mRNA to regulate mRNA stability or translational efficiency, thereby fine-tuning gene expression. In the present review, we discuss… CONTINUE READING


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