mRNA-binding protein ZFP36 is expressed in atherosclerotic lesions and reduces inflammation in aortic endothelial cells.

@article{Zhang2013mRNAbindingPZ,
  title={mRNA-binding protein ZFP36 is expressed in atherosclerotic lesions and reduces inflammation in aortic endothelial cells.},
  author={Huanchun Zhang and William Robert Taylor and Giji Joseph and Valentina Caracciolo and Donna M. Gonzales and Neil Sidell and Emre Seli and Perry J. Blackshear and Caleb B. Kallen},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 6},
  pages={
          1212-20
        }
}
OBJECTIVE We studied the expression and function of an mRNA-binding protein, zinc finger protein-36 (ZFP36), in vascular endothelial cells in vivo and in vitro. We tested the hypotheses that ZFP36 regulates inflammation in vascular endothelial cells and that it functions through direct binding to target cytokine mRNAs. We also tested whether ZFP36 inhibits nuclear factor-κB-mediated transcriptional responses in vascular endothelial cells. APPROACH AND RESULTS ZFP36 was minimally expressed in… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS