mRNA-based therapeutics — developing a new class of drugs

@article{ahin2014mRNAbasedT,
  title={mRNA-based therapeutics — developing a new class of drugs},
  author={Uğur Şahin and Katalin Karik{\'o} and {\"O}zlem T{\"u}reci},
  journal={Nature Reviews Drug Discovery},
  year={2014},
  volume={13},
  pages={759-780}
}
In vitro transcribed (IVT) mRNA has recently come into focus as a potential new drug class to deliver genetic information. Such synthetic mRNA can be engineered to transiently express proteins by structurally resembling natural mRNA. Advances in addressing the inherent challenges of this drug class, particularly related to controlling the translational efficacy and immunogenicity of the IVTmRNA, provide the basis for a broad range of potential applications. mRNA-based cancer immunotherapies and… 
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