mRNA and protein expression of PUMA in sporadic colorectal cancer.

@article{Jansson2004mRNAAP,
  title={mRNA and protein expression of PUMA in sporadic colorectal cancer.},
  author={Agneta K Jansson and Gunnar Arbman and Xiaofeng Sun},
  journal={Oncology reports},
  year={2004},
  volume={12 6},
  pages={1245-9}
}
PUMA is a BH3-only member of the Bcl-2 family, up-regulated by p53 as a response to DNA damage. We have investigated the mRNA expression of PUMA with real-time PCR in 94 colorectal adenocarcinomas and the corresponding normal mucosa. Among them PUMA protein expression was investigated with immunohistochemistry in 23 tumours and 17 corresponding normal mucosa samples. The mRNA expression of PUMA decreased in 4% and increased in 4% of the tumours compared with the normal mucosa. The protein… CONTINUE READING