mRNA and microRNA Expression Profiles in Circulating Tumor Cells and Primary Tumors of Metastatic Breast Cancer Patients

@article{Sieuwerts2011mRNAAM,
  title={mRNA and microRNA Expression Profiles in Circulating Tumor Cells and Primary Tumors of Metastatic Breast Cancer Patients},
  author={A. Sieuwerts and B. Mostert and J. Bolt-de Vries and D. Peeters and F. D. de Jongh and J. Stouthard and L. Dirix and P. V. van Dam and A. van Galen and Vanja de Weerd and J. Kraan and P. van der Spoel and Raquel Ram{\'i}rez-Moreno and C. V. van Deurzen and M. Smid and J. X. Yu and J. Jiang and Y. Wang and J. Gratama and S. Sleijfer and J. Foekens and J. Martens},
  journal={Clinical Cancer Research},
  year={2011},
  volume={17},
  pages={3600 - 3618}
}
  • A. Sieuwerts, B. Mostert, +19 authors J. Martens
  • Published 2011
  • Medicine, Biology
  • Clinical Cancer Research
  • Purpose: Molecular characterization of circulating tumor cells (CTC) holds great promise. Unfortunately, routinely isolated CTC fractions currently still contain contaminating leukocytes, which makes CTC-specific molecular characterization extremely challenging. In this study, we determined mRNA and microRNA (miRNA) expression of potentially CTC-specific genes that are considered to be clinically relevant in breast cancer. Experimental Design: CTCs were isolated with the epithelial cell… CONTINUE READING
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