mRNA Targeting to Endoplasmic Reticulum

@inproceedings{Barman2015mRNATT,
  title={mRNA Targeting to Endoplasmic Reticulum},
  author={Bahnisikha Barman and Suvendra N Bhattacharyya},
  year={2015}
}
Background: miRNA, Ago2, and target messages are enriched on ER in metazoan cells. Results: Polysome association of newly formed mRNA precedes Ago2 binding on ER membrane and its translation repression. Conclusion: miRNA repression process is compartmentalized in mammalian cells, and polysome association of mRNA happens before the repression. Significance: This work provides a detailed understanding of the miRNA-mediated gene repression and mRNA compartmentalization in mammalian cells. 

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