mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships

@article{Bujnicki2001mRNAguanineN7CM,
  title={mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships},
  author={Janusz M. Bujnicki and Marcin Feder and Monika Radlinska and Leszek Rychlewski},
  journal={BMC Bioinformatics},
  year={2001},
  volume={2},
  pages={2 - 2}
}
The 5'-terminal cap structure plays an important role in many aspects of mRNA metabolism. Capping enzymes encoded by viruses and pathogenic fungi are attractive targets for specific inhibitors. There is a large body of experimental data on viral and cellular methyltransferases (MTases) that carry out guanine-N7 (cap 0) methylation, including results of extensive mutagenesis. However, a crystal structure is not available and cap 0 MTases are too diverged from other MTases of known structure to… CONTINUE READING