mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression

@article{Sans2005mPinsMP,
  title={mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression},
  author={Nathalie Sans and Philip Y. Wang and Quansheng Du and Ronald S. Petralia and Ya-xian Wang and Sajan Nakka and Joe B Blumer and Ian G. Macara and Robert J. Wenthold},
  journal={Nature Cell Biology},
  year={2005},
  volume={7},
  pages={1179-1190}
}
Appropriate trafficking and targeting of glutamate receptors (GluRs) to the postsynaptic density is crucial for synaptic function. We show that mPins (mammalian homologue of Drosophila melanogaster partner of inscuteable) interacts with SAP102 and PSD-95 (two PDZ proteins present in neurons), and functions in the formation of the NMDAR–MAGUK (N-methyl-D-aspartate receptor–membrane-associated guanylate kinase) complex. mPins enhances trafficking of SAP102 and NMDARs to the plasma membrane in… CONTINUE READING
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partners in signaling

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