mPGES-1 deletion impairs aldosterone escape and enhances sodium appetite.

  title={mPGES-1 deletion impairs aldosterone escape and enhances sodium appetite.},
  author={Zhanjun Jia and Toshinori Aoyagi and Donald E Kohan and Tianxin Yang},
  journal={American journal of physiology. Renal physiology},
  volume={299 1},
Aldosterone (Aldo) is a major sodium-retaining hormone that reduces renal sodium excretion and also stimulates sodium appetite. In the face of excess Aldo, the sodium-retaining action of this steroid is overridden by an adaptive regulatory mechanism, a phenomenon termed Aldo escape. The underlying mechanism of this phenomenon is not well defined but appeared to involve a number of natriuretic factors such prostaglandins (PGs). Here, we investigated the role of microsomal prostaglandin E… CONTINUE READING
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