mHDA1/HDAC5 Histone Deacetylase Interacts with and Represses MEF2A Transcriptional Activity*

  title={mHDA1/HDAC5 Histone Deacetylase Interacts with and Represses MEF2A Transcriptional Activity*},
  author={Claudie Lemercier and Andr{\'e} Verdel and Bertrand Galloo and Sandrine Curtet and M P Brocard and Saadi Khochbin},
  journal={The Journal of Biological Chemistry},
  pages={15594 - 15599}
Recently we identified a new family of histone deacetylases in higher eukaryotes related to yeast HDA1 and showed their differentiation-dependent expression. Data presented here indicate that HDAC5 (previously named mHDA1), one member of this family, might be a potent regulator of cell differentiation by interacting specifically with determinant transcription factors. We found that HDAC5 was able to interact in vivo and in vitro with MEF2A, a MADS box transcription factor, and to strongly… 

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