mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082.

@article{Pelkey2007mGluR7UR,
  title={mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082.},
  author={Kenneth A. Pelkey and Xiaoqing Yuan and Gabriela Lavezzari and Katherine W. Roche and Chris J McBain},
  journal={Neuropharmacology},
  year={2007},
  volume={52 1},
  pages={108-17}
}
The G-protein coupled receptor (GPCR) metabotropic glutamate receptor 7 (mGluR7) is widely expressed throughout the nervous system and is implicated in diverse physiological processes ranging from synaptic plasticity to neuroprotection. To date, unequivocally assigning specific functions to mGluR7 has been hampered by a lack of specific pharmacological tools, however, an mGluR7 specific allosteric agonist, AMN082, was recently discovered. Accumulating evidence indicates that in addition to G… CONTINUE READING
44 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

Similar Papers

Loading similar papers…