mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration.

@article{Cleva2011mGluR5PA,
  title={mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration.},
  author={Richard M. Cleva and Megan P. Hicks and Justin T Gass and Kelly C. Wischerath and Elizabeth T Plasters and John J. Widholm and M Foster Olive},
  journal={Behavioral neuroscience},
  year={2011},
  volume={125 1},
  pages={10-9}
}
Extinction of classically and instrumentally conditioned behaviors, such as conditioned fear and drug-seeking behavior, is a process of active learning, and recent studies indicate that potentiation of glutamatergic transmission facilitates extinction learning. In this study, the authors investigated the effects of the Type-5 metabotropic glutamate receptors (mGluR5) positive allosteric modulator 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) on the extinction of cocaine-seeking… CONTINUE READING
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