Corpus ID: 151718015

mGluR5 Positive Allosteric Modulation as a Novel Therapeutic Target for the Cognitive Deficits Associated with Schizophrenia

@inproceedings{Lacrosse2014mGluR5PA,
  title={mGluR5 Positive Allosteric Modulation as a Novel Therapeutic Target for the Cognitive Deficits Associated with Schizophrenia},
  author={Amber L. Lacrosse},
  year={2014}
}
  • Amber L. Lacrosse
  • Published 2014
  • Psychology
  • Rationale Positive allosteric modulators (PAMs) of type 5 metabotropic glutamate receptors (mGluR5) exert pro-cognitive effects in animal models of various neuropsychiatric diseases. However, few studies to date have examined ability of mGluR5 PAMs to reverse cognitive deficits in operant delayed matching/non-matchingto-sample (DMS/DNMS) tasks. Objectives To determine the ability of the mGluR5 PAM 3-cyano-N-1,3-diphenyl-1Hpyrazol-5-yl)benzamide (CDPPB) to reverse set-shifting deficits induced… CONTINUE READING

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