mGluR5 Ablation in Cortical Glutamatergic Neurons Increases Novelty-Induced Locomotion

  title={mGluR5 Ablation in Cortical Glutamatergic Neurons Increases Novelty-Induced Locomotion},
  author={Chris P. Jew and C Wu and Hao Sun and Jie Zhu and Jui-Yen Huang and Dinghui Yu and Nicholas Justice and Hui-Chen Lu},
  booktitle={PloS one},
The group I metabotropic glutamate receptor 5 (mGluR5) has been implicated in the pathology of various neurological disorders including schizophrenia, ADHD, and autism. mGluR5-dependent synaptic plasticity has been described at a variety of neural connections and its signaling has been implicated in several behaviors. These behaviors include locomotor reactivity to novel environment, sensorimotor gating, anxiety, and cognition. mGluR5 is expressed in glutamatergic neurons, inhibitory neurons… CONTINUE READING


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Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex

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  • PLoS ONE
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