mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: Evidence for both presynaptic and postsynaptic actions

@inproceedings{Jin2016mGluR23MI,
  title={mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: Evidence for both presynaptic and postsynaptic actions},
  author={Lu E. Jin and Min Wang and S Yang and Yang Yang and Veronica C Galvin and Taber C. Lightbourne and David Ottenheimer and Qiaonan Zhong and Josh Stein and Anusha Raja and Constantinos D. Paspalas and Amy F. T. Arnsten},
  booktitle={Molecular Psychiatry},
  year={2016}
}
Cognitive deficits in psychiatric and age-related disorders generally involve dysfunction of the dorsolateral prefrontal cortex (dlPFC), but there are few treatments for these debilitating symptoms. Group II metabotropic glutamate receptors (mGluR2/3), which couple to Gi/Go, have been a focus of therapeutics based on rodent research, where mGluR2/3 have been shown to reduce axonal glutamate release and increase glial glutamate uptake. However, this strategy has had mixed results in patients… CONTINUE READING