mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C

@article{Skeberdis2001mGluR1mediatedPO,
  title={mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C},
  author={V. A. Skeberdis and Jian-yu Lan and T. Opitz and X. Zheng and R. S. Zukin},
  journal={Neuropharmacology},
  year={2001},
  volume={40},
  pages={856-865}
}
  • V. A. Skeberdis, Jian-yu Lan, +2 authors R. S. Zukin
  • Published 2001
  • Medicine, Biology
  • Neuropharmacology
  • Potentiation of ionotropic glutamate receptor activity by metabotropic glutamate receptors (mGluRs) is thought to modulate activity at glutamatergic synapses in the hippocampus. However, the precise pathway by which this modulation occurs is not well understood. The present study tests the hypothesis that mGluR1-mediated potentiation of N-methyl-D-aspartate receptors (NMDARs) occurs via a phospholipase C (PLC)-initiated cascade. NMDAR functional activity was examined by whole-cell recording… CONTINUE READING
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