mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C

@article{Skeberdis2001mGluR1mediatedPO,
  title={mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C},
  author={Vytenis Arvydas Skeberdis and Jian-yu Lan and Thoralf Opitz and Xin Zheng and Michael V. L. Bennett and R Suzanne Zukin},
  journal={Neuropharmacology},
  year={2001},
  volume={40},
  pages={856-865}
}
Potentiation of ionotropic glutamate receptor activity by metabotropic glutamate receptors (mGluRs) is thought to modulate activity at glutamatergic synapses in the hippocampus. However, the precise pathway by which this modulation occurs is not well understood. The present study tests the hypothesis that mGluR1-mediated potentiation of N-methyl-D-aspartate receptors (NMDARs) occurs via a phospholipase C (PLC)-initiated cascade. NMDAR functional activity was examined by whole-cell recording… Expand
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References

SHOWING 1-10 OF 42 REFERENCES
Metabotropic Glutamate Receptors Activate G-Protein-Coupled Inwardly Rectifying Potassium Channels in XenopusOocytes
TLDR
The efficient coupling of mGluRs to GIRK in oocytes suggests either that mGLUR activation of GIRk has been overlooked in neurons or possibly that mgluRs are excluded from GirK-containing microdomains. Expand
Ca2+ Influx Amplifies Protein Kinase C Potentiation of Recombinant NMDA Receptors
TLDR
Ca2+ influx through PKC-potentiated NMDA receptors can further increase the NMDA response and be affected by Ca2+ amplification of the potentiated signal; the degree of amplification will depend in part on alternative splicing of the NR1 subunit, which is regulated developmentally and in a cell-specific manner. Expand
Activation of Metabotropic Glutamate Receptor 1 Accelerates NMDA Receptor Trafficking
TLDR
In Xenopus oocytes expressing recombinant receptors, activation of mGluR1 potentiates NMDA channel activity by recruitment of new channels to the plasma membrane via regulated exocytosis through mGLUR1α-mediated potentiation of NMDARs. Expand
Activation of the extracellular signal‐regulated kinase 2 by metabotropic glutamate receptors
TLDR
Findings raise the possibility of a MAPK cascade involvement in glutamate‐dependent neuronal plasticity mediated through stimulation of mGluRs in the control of cellular responses to changes in the external environment. Expand
Protein kinase C‐mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes.
TLDR
A role for metabotropic glutamate receptors in modulation of NMDA‐mediated processes is suggested in Xenopus oocytes injected with rat brain RNA and under conditions that eliminate the oocyte's endogenous calcium‐dependent chloride current. Expand
Regulation of N-methyl-D-aspartate receptor function by constitutively active protein kinase C.
TLDR
Application of PKM to inside-out patches taken from cultured neurons increased the probability of channel opening without changing single-channel current amplitudes or channel open times, indicating the activation of protein kinase C is associated with potentiation of NMDA receptor function in hippocampal neurons largely through an increase in the probabilityof channel opening. Expand
Metabotropic glutamate receptors modulateN-methyl-d-aspartate receptor function in neostriatal neurons
TLDR
It was found that the iontophoretic application of the metabotropic glutamate receptor agonist 1-amino-cyclopentane-1,3-dicarboxylic acid markedly attenuated both the amplitude and duration of excitatory responses induced by the ionTophoretics application of N-methyl-D-aspartate. Expand
Protein kinase C potentiation of N-methyl-D-aspartate receptor activity is not mediated by phosphorylation of N-methyl-D-aspartate receptor subunits.
TLDR
The results indicate that PKC-induced potentiation of NMDAR activity does not occur by direct phosphorylation of the receptor protein but rather of associated targeting, anchoring, or signaling protein(s) and may play a role in NMDA-dependent long-term potentiation. Expand
Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems
TLDR
Evidence is found that this response is mediated by activation of a protein phosphatase and a resultant dephosphorylation of protein kinase C phosphorylation sites on mGluR5, which may be important in a number of normal and pathological processes that involve activation of the NMDA receptor. Expand
Activation of group I mG1uRs potentiates NMDA responses in rat hippocampal slices
The pharmacology of the metabotropic glutamate receptor (mGluR)-mediated potentiation of N-methyl-D-aspartate (NMDA)-evoked depolarisations in the CA1 region of rat hippocampal slices wasExpand
...
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4
5
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