mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus.

@article{Errington2011mGluRCO,
  title={mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus.},
  author={Adam C Errington and Giuseppe Di Giovanni and Vincenzo Crunelli and David W. Cope},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 23},
  pages={8669-80}
}
Metabotropic glutamate receptors (mGluRs) play a crucial role in regulation of phasic inhibition within the visual thalamus. Here we demonstrate that mGluR-dependent modulation of interneuron GABA release results in dynamic changes in extrasynaptic GABA(A) receptor (eGABA(A)R)-dependent tonic inhibition in thalamocortical (TC) neurons of the rat dorsal lateral geniculate nucleus (dLGN). Application of the group I selective mGluR agonist dihydroxyphenylglycine produces a concentration-dependent… CONTINUE READING
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