mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia.

@article{Walker2001mGlu5RA,
  title={mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia.},
  author={Katharine Walker and Alison J. Reeve and Mick Bowes and Janet K. Winter and Glen Wotherspoon and Amelia Davis and Peter Schmid and Fabrizio Gasparini and Rainer Kuhn and Laszlo Urban},
  journal={Neuropharmacology},
  year={2001},
  volume={40 1},
  pages={10-9}
}
Previous studies have demonstrated that the metabotropic glutamate receptor subtype 5 (mGlu5 receptor) is expressed in the cell bodies of rat primary afferent neurones. We have further investigated the function and expression of mGlu5 receptors in primary afferent neurones, and their role in inflammatory nociception. Freund's complete adjuvant-induced inflammatory hyperalgesia of the rat hind paw was significantly reduced by intraplantar, but not by intracerebroventricular or intrathecal… CONTINUE READING
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