mGlu5 receptor antagonists: a novel class of anxiolytics?

  title={mGlu5 receptor antagonists: a novel class of anxiolytics?},
  author={Will P. J. M. Spooren and Fabrizio Gasparini},
  journal={Drug news & perspectives},
  volume={17 4},
In the early 1990s, a new family of receptors were cloned that were found to mediate the intracellular metabolic effects of glutamate via coupling to secondary messenger systems, that is, the metabotropic glutamate (mGlu) receptors. Eight such receptors (mGlu1 to mGlu8) have been cloned to date, and according to their amino acid sequence, pharmacology and second-messenger coupling, these receptors have been clustered into three groups (I-III). In contrast to the glutamate-gated ion channels… CONTINUE READING


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