mGLU3 metabotropic glutamate receptors modulate the differentiation of SVZ-derived neural stem cells towards the astrocytic lineage.

@article{Ciceroni2010mGLU3MG,
  title={mGLU3 metabotropic glutamate receptors modulate the differentiation of SVZ-derived neural stem cells towards the astrocytic lineage.},
  author={Cinzia Ciceroni and P. Mosillo and E Mastrantoni and Patrizio Sale and Lucia Ricci-Vitiani and Francesca Biagioni and Fabrizio Stocchi and Ferdinando Nicoletti and Daniela Melchiorri},
  journal={Glia},
  year={2010},
  volume={58 7},
  pages={
          813-22
        }
}
Neural stem cells (NSCs) isolated from the subventricular zone (SVZ) of postnatal mice, and cultured as neurospheres, expressed functional mGlu3 receptors. Following mitogen withdrawal and plating onto poly-ornitine-coated dishes, cells dissociated from the neurospheres differentiated into GFAP(+) astrocytes (about 85%), and a small percentage of beta-III tubulin(+)-neurons and O1(+)-oligodendrocytes. Activation of mGlu3 receptors with LY379268 (100 nM, applied every other day), during the… CONTINUE READING

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