mCD14 expression in human monocytes is downregulated by ouabain via transactivation of epithelial growth factor receptor and activation of p38 mitogen-activated protein kinase.

@article{Valente2009mCD14EI,
  title={mCD14 expression in human monocytes is downregulated by ouabain via transactivation of epithelial growth factor receptor and activation of p38 mitogen-activated protein kinase.},
  author={Raphael do Carmo Valente and Clarissa Rodrigues Nascimento and Elizabeth Giestal de Ara{\'u}jo and Vivian M. Rumjanek},
  journal={Neuroimmunomodulation},
  year={2009},
  volume={16 4},
  pages={228-36}
}
BACKGROUND AND AIMS The steroid ouabain is found in plasma and in many mammalian tissues, and is now considered as a hormone. In the immune system, ouabain regulates a number of lymphocyte functions, but little is known about its effects on monocyte function. Monocytes are important for adequate immune responses. The aim of this work was to analyze the effect of ouabain on mCD14 expression, a surface molecule involved in the response against Gram-negative bacteria and phagocytosis. METHODS… CONTINUE READING

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