mAbs and Ad-vectored IFN-α therapy rescue Ebola-infected nonhuman primates when administered after the detection of viremia and symptoms.

@article{Qiu2013mAbsAA,
  title={mAbs and Ad-vectored IFN-α therapy rescue Ebola-infected nonhuman primates when administered after the detection of viremia and symptoms.},
  author={Xiangguo Qiu and Gary W-K Wong and L. B. Fernando and Jonathan Audet and Alexander J Bello and Jim E. Strong and Judie B. Alimonti and Gary P Kobinger},
  journal={Science translational medicine},
  year={2013},
  volume={5 207},
  pages={
          207ra143
        }
}
ZMAb is a promising treatment against Ebola virus (EBOV) disease that has been shown to protect 50% (two of four) of nonhuman primates (NHPs) when administered 2 days post-infection (dpi). To extend the treatment window and improve protection, we combined ZMAb with adenovirus-vectored interferon-α (Ad-IFN) and evaluated efficacy in EBOV-infected NHPs. Seventy-five percent (three of four) and 100% (four of four) of cynomolgus and rhesus macaques survived, respectively, when treatment was… CONTINUE READING
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