m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition

  title={m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition},
  author={Boxuan Simen Zhao and Xiao Wang and Alana V. Beadell and Zhike Lu and Hailing Shi and Adam Kuuspalu and Robert K. Ho and Chuan He},
The maternal-to-zygotic transition (MZT) is one of the most profound and tightly orchestrated processes during the early life of embryos, yet factors that shape the temporal pattern of vertebrate MZT are largely unknown. Here we show that over one-third of zebrafish maternal messenger RNAs (mRNAs) can be N6-methyladenosine (m6A) modified, and the clearance of these maternal mRNAs is facilitated by an m6A-binding protein, Ythdf2. Removal of Ythdf2 in zebrafish embryos decelerates the decay of… CONTINUE READING
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ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells.

Proceedings of the National Academy of Sciences of the United States of America • 2018
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