m6A RNA methylation regulates the fate of endogenous retroviruses

@article{Chelmicki2020m6ARM,
  title={m6A RNA methylation regulates the fate of endogenous retroviruses},
  author={Tomasz Chelmicki and Emeline Roger and Aurelie Teissandier and Sofia Rucli and François Dossin and M. Dura and Camille Fouassier and Sonia Lameiras and D. Bourc’his},
  journal={bioRxiv},
  year={2020}
}
Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that impact genome regulation and cell physiology throughout their RNA-centered life cycle1. Failure to repress ERVs is associated with cancer, infertility, senescence and neurodegenerative diseases2–4. Here, using an unbiased genome-scale CRISPR knockout screen in mouse embryonic stem cells, we identify m6A RNA methylation as a novel means of ERV restriction. Methylation of ERV mRNAs is… Expand
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[基金项目] 国家科技重大专项课题资助项目(No.2017ZX10203206-002);国家自然科学基金资助项目(No.81972683);上海市青年科技启明星 计划资助项目(No. 19QA1411300)。 Project supported by the National Science and Technology Major Project (No.Expand
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