m-Hydroxybenzoylecgonine: an important contributor to the immunoreactivity in assays for benzoylecgonine in meconium.

@article{Steele1993mHydroxybenzoylecgonineAI,
  title={m-Hydroxybenzoylecgonine: an important contributor to the immunoreactivity in assays for benzoylecgonine in meconium.},
  author={Bernard W. Steele and Emmalee S. Bandstra and Nini Wu and George W Hime and William Lee Hearn},
  journal={Journal of analytical toxicology},
  year={1993},
  volume={17 6},
  pages={
          348-52
        }
}
Meconium has been reported to be a more suitable specimen than maternal or neonatal urine for detecting fetal exposure to cocaine. In a study comparing various immunoassays with gas chromatography/mass spectrometry (GC/MS), several unexplained discrepancies among the assays were noted. Using methanol extracts of meconium samples, an immunoreactive spot that was more polar than benzoylecgonine was detected by thin-layer chromatography (TLC). An extract of this spot analyzed by GC/MS yielded a… CONTINUE READING