m-Chlorophenylpiperazine effects in neuroleptic-free schizophrenic patients. Evidence implicating serotonergic systems in the positive symptoms of schizophrenia.

@article{Krystal1993mChlorophenylpiperazineEI,
  title={m-Chlorophenylpiperazine effects in neuroleptic-free schizophrenic patients. Evidence implicating serotonergic systems in the positive symptoms of schizophrenia.},
  author={John H. Krystal and John P. Seibyl and Lawrence H. Price and Scott W. Woods and George R. Heninger and George K. Aghajanian and Dennis S. Charney},
  journal={Archives of general psychiatry},
  year={1993},
  volume={50 8},
  pages={
          624-35
        }
}
OBJECTIVE This study evaluated whether alterations in serotonin function in schizophrenic patients could be demonstrated by comparing the reactivity to a serotonin partial agonist, m-chlorophenylpiperazine (MCPP) in patients and healthy subjects. This study also assessed whether stimulation of serotonin receptors influenced the symptoms of schizophrenia. DESIGN Double-blind randomized comparison of MCPP (0.1 mg/kg, intravenously, administered over 20 minutes) and placebo effects in patients… CONTINUE READING

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