lon-1 regulates Caenorhabditis elegans body size downstream of the dbl-1 TGF beta signaling pathway.

@article{Maduzia2002lon1RC,
  title={lon-1 regulates Caenorhabditis elegans body size downstream of the dbl-1 TGF beta signaling pathway.},
  author={Lisa L. Maduzia and Tina L. Gumienny and Cole Zimmerman and Huang Wang and Pradnya Shetgiri and Srikant Krishna and Andrew F. Roberts and Richard W Padgett},
  journal={Developmental biology},
  year={2002},
  volume={246 2},
  pages={418-28}
}
In Caenorhabditis elegans, two well-characterized TGF beta signaling cascades have been identified: the Small/Male tail abnormal (Sma/Mab) and Dauer formation (Daf) pathways. The Sma/Mab pathway regulates body size morphogenesis and male tail development. The ligand of the pathway, dbl-1, transmits its signal through two receptor serine threonine kinases, daf-4 and sma-6, which in turn regulate the activity of the Smads, sma-2, sma-3, and sma-4. In general, Smads have been shown to both… CONTINUE READING

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