lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

@article{Nourse1994lnterleukin2mediatedEO,
  title={lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin},
  author={Jamison Nourse and Eduardo J. Firpo and W. Michael Flanagan and Steve Coats and Kornelia Polyak and Mong Hong Lee and Joan Massagu{\'e} and Gerald R Crabtree and James M Roberts},
  journal={Nature},
  year={1994},
  volume={372},
  pages={570-573}
}
THE cyclin-dependent kinase (Cdk) enzymes, when associated with the G1 cyclins D and E, are rate-limiting for entry into the S phase of the cell cycle1,2. During T-cell mitogenesis, antigen–receptor signalling promotes synthesis of cyclin E and its catalytic partner, Cdk2, and interleukin-2 (IL-2) signalling activates cyclin E/Cdk2 complexes3. Rapamycin is a potent immunosuppressant which specifically inhibits Gl-to-S-phase progression, leading to cell-cycle arrest in yeast and mammals4–7. Here… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 235 extracted citations

Similar Papers

Loading similar papers…