lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

@article{Minty1993lnterleukin13IA,
  title={lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses},
  author={Adrian J. Minty and Pascale Chalon and Jean Marie Derocq and Xavier Dumont and Jean Claude Guillemot and Mourad Kaghad and Caroline Labit and Pascal Leplatois and P. Liauzun and Brigitte Miloux and C. Minty and Pierre Casellas and Gérard Loison and Jan H. Lupker and David Shire and Pascual Ferrara and Daniel Caput},
  journal={Nature},
  year={1993},
  volume={362},
  pages={248-250}
}
THE discovery of new cytokines normally relies on a prior knowledge of at least one of their biological effects, which is used as a criterion either for the purification of the protein or for the isolation of the complementary DNA by expression cloning. However, the redundancy of cytokine activities complicates the discovery of novel cytokines in this way, and the pleiotropic nature of many cytokines means that the principal activities of a new cytokine may bear little relation to that used for… 
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TLDR
The importance ofCD28-delivered costimulatory signals was proven in experiments with CD28-deficient mice, which exhibited an impaired pattern of cytokine secretion and defects in T cell-dependent antibody production.
Interleukin-13: characterization and biologic properties.
TLDR
The current understanding of how IL-13 is utilized in immune reactions is discussed, and it is now clear that this mechanism is repetitively utilized in the immune system.
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TLDR
The signaling pathways initiated by TCR, CD28, and CD7 are reviewed, as well as the functional consequences of signal transduction through these receptors.
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TLDR
The results suggest that the inhibition of PMA-induced HA adhesion by IFN-gamma and IL-4 may influence B cell migration through their ability to downregulate CD44-HA interactions.
Molecular Modeling of Cytokines and Their Receptors*
TLDR
This work uses computer-aided molecular modeling to attempt to explain the functions of the cytokines interleukin 2 (IL2), IIA, IL13, and the related granulocyte macrophage colony stimulating factor (GM-CSF).
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