lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

  title={lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses},
  author={Adrian J. Minty and Pascale Chalon and Jean Marie Derocq and Xavier Dumont and Jean Claude Guillemot and Mourad Kaghad and Caroline Labit and Pascal Leplatois and P. Liauzun and Brigitte Miloux and C. Minty and Pierre Casellas and Gérard Loison and Jan H. Lupker and David Shire and Pascual Ferrara and Daniel Caput},
THE discovery of new cytokines normally relies on a prior knowledge of at least one of their biological effects, which is used as a criterion either for the purification of the protein or for the isolation of the complementary DNA by expression cloning. However, the redundancy of cytokine activities complicates the discovery of novel cytokines in this way, and the pleiotropic nature of many cytokines means that the principal activities of a new cytokine may bear little relation to that used for… 

Lymphokines and Cytokines

It is now recognized that cytokines may function in a wide range of activities, including regulation of immunological and inflammatory processes, which not only regulate normal cell growth and differentiation but also participate in repair mechanisms.

Contamination with Mycoplasma spp. induces interleukin-13 expression by human skin fibroblasts in culture.

It is found that human fibroblasts that have been contaminated with mycoplasma show production of IL-13 at the transcriptional level, and this is the first report to acknowledge that myCoplasma contamination can induce mRNA expression for IL- 13 in cultured human fib roblasts.

CD28 costimulatory molecule--expression, structure and function.

The importance ofCD28-delivered costimulatory signals was proven in experiments with CD28-deficient mice, which exhibited an impaired pattern of cytokine secretion and defects in T cell-dependent antibody production.

Interleukin-13: characterization and biologic properties.

The current understanding of how IL-13 is utilized in immune reactions is discussed, and it is now clear that this mechanism is repetitively utilized in the immune system.

T cell signal transfuction and the role of CD7 in costimulation

The signaling pathways initiated by TCR, CD28, and CD7 are reviewed, as well as the functional consequences of signal transduction through these receptors.

Interferon-gamma inhibits CD44-hyaluronan interactions in normal human B lymphocytes.

The results suggest that the inhibition of PMA-induced HA adhesion by IFN-gamma and IL-4 may influence B cell migration through their ability to downregulate CD44-HA interactions.

Molecular Modeling of Cytokines and Their Receptors*

This work uses computer-aided molecular modeling to attempt to explain the functions of the cytokines interleukin 2 (IL2), IIA, IL13, and the related granulocyte macrophage colony stimulating factor (GM-CSF).



CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

It is shown that CD28 stimulation augments T- cell immune responses by specifically inducing a 5- to 50-fold enhancement in the expression and secretion of interleukin 2, tumor necrosis factor type alpha, lymphotoxin, interferon gamma, and granulocyte-macrophage colony-stimulating factor in normal human T cells stimulated to proliferate by crosslinking of the T-cell receptor/CD3 complex.

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

Data strongly suggest that the same molecule mediates these three activities, although the presence of traces of contaminant peptides even in the most purified NKSF preparations does not allow us to exclude the possibility that distinct biologically active molecules have been co-purified.

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

  • C. GimmiG. Freeman L. Nadler
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1991
B7-transfected CHO cells can induce suboptimally activated CD28+ T cells to proliferate and secrete high levels of interleukin 2, and this response is identical whether T cells are submitogenically stimulated with either phorbol myristate acetate or anti-CD3 to activate the T cells.

Production of hybridoma growth factor by human monocytes

Limiting dilution analysis of the producing cells in combination with size, density and adherence characteristics showed that HGF is produced by monocytes and not by lymphocytes, and there was no need for the monocytes to be stimulated but the cells did require the presence of serum.

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

It is shown that the CD28 antigen, expressed in Chinese hamster ovary cells, mediated specific intercellular adhesion with human lymphoblastoid and leukemic B-cell lines and with activated primary murine B cells, and represents a heterophilic interaction between members of the immunoglobulin superfamily that may serve to regulate T-cell cytokine levels at sites of B- cell activation.

A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes.

One of the small, inducible, secreted proteins has a predicted mature N terminus identical to that of the previously described macrophage inflammatory protein.

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

Evidence is presented here to show that one type of helper T cell clone (TH1) causes delayed-type hypersensitivity (DTH) when injected with the appropriate antigen into the footpads of naive mice.

Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes

It is demonstrated that T cells that differ in lymphokine production also differ in their ability to help B cells as a result of cognate interactions at low concentrations of antigens.

IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis.

  • P. Scott
  • Biology
    Journal of immunology
  • 1991
Levels of IFN-gamma at the time of infection or immunization dramatically alters the type of response elicited: high levels ofIFN-Gamma favor Th1 type responses, whereas low levels promote a Th2 response.