lncRNA TPTEP1 competitively sponges miR-328-5p to inhibit the proliferation of non-small cell lung cancer cells

@article{Cao2020lncRNATC,
  title={lncRNA TPTEP1 competitively sponges miR-328-5p to inhibit the proliferation of non-small cell lung cancer cells},
  author={F-L Cao and Zhiguo Wang and Yong Feng and HongJun Zhu and Mei Yang and Shuanglin Zhang and Xuefeng Wang},
  journal={Oncology Reports},
  year={2020},
  volume={43},
  pages={1606 - 1618}
}
Accumulating evidence suggests that lncRNAs are involved in almost all normal physiological processes and that aberrant expression of lncRNAs may be involved in the development of diseases, including non-small cell lung cancer (NSCLC). However, the roles of lncRNA-TPTE pseudogene 1 (TPTEP1) in lung cancer and the underlying molecular mechanisms have remained elusive. In the present study, significant downregulation of TPTEP1 in tumors compared with normal tissues from patients with NSCLC was… 

Figures and Tables from this paper

LncRNA TPTEP1 inhibited the proliferation and metastasis of non-small cell lung cancer cells by targeting miR-761/LATS2 axis.
TLDR
The study showed that TPTEP1 played an inhibitory role in cancer progression of NSCLC cells by regulating miR-761/LATS2 cascade, thereby highlighting the potential therapeutic significance of T PTEP1/miR- 761/ LATS2 axis.
Long non-coding RNA TPTEP1 exerts inhibitory effects on hepatocellular carcinoma by impairing microRNA-454-3p-mediated DLG5 downregulation.
The LINC01260 Functions as a Tumor Suppressor via the miR-562/CYLD/NF-κB Pathway in Non-Small Cell Lung Cancer
TLDR
A novel LINC01260/miR-562/CYLD/NF-κB pathway in the pathogenesis of NSCLC is revealed and suggested a potential therapeutic target forNSCLC.
Overexpression of DDIT4 and TPTEP1 are associated with metastasis and advanced stages in colorectal cancer patients: a study utilizing bioinformatics prediction and experimental validation
TLDR
Increased expression levels of DDIT4 and TPTEP1 in CRC were associated with more aggressive tumor behavior and more advanced stages of the disease, suggesting a regulatory effect of T PTEP1 on these genes.
Long non-coding RNA MCM3AP antisense RNA 1 promotes non-small cell lung cancer progression through targeting microRNA-195-5p
TLDR
MCM3AP-AS1, serving as a competitive endogenous RNA (ceRNA) to regulate miR-195-5p/E2F3 axis, promotes non-small cell lung cancer progression, which is a promising therapeutic target for NSCLC.
miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells
TLDR
These ncRNAs regulate key genes belonging to pathways involved in cell senescence and prostate cancer demonstrating their central role in these processes and opening the possibility for their use as biomarkers or therapeutic targets to mitigate against prostate ageing and carcinogenesis.
LncRNA-RMST Functions as a Transcriptional Co-regulator of SOX2 to Regulate miR-1251 in the Progression of Hirschsprung's Disease
TLDR
It is demonstrated that RMST functioned as a transcriptional co-regulator of SOX2 to regulate miR-1251 and resulted in the upregulation of AHNAK, leading to the occurrence of HSCR.
lncRNA-RMST functioned as a SOX2 transcription co-regulator to regulate miR-1251 in the progression of Hirschsprung’s disease
TLDR
The role of RMST/SOX2/miR-1251/AHNAK pathway in the occurrence of Hirschsprung’s disease was revealed and provided a potential therapeutic target for this disease.
LINC00460 Is a Dual Biomarker That Acts as a Predictor for Increased Prognosis in Basal-Like Breast Cancer and Potentially Regulates Immunogenic and Differentiation-Related Genes
TLDR
It is shown that the LINC00460 prognostic expression effect is tissue-specific, since its upregulation can predict poor OS in some tumors, but also predicts an improved clinical course in BRCA patients.
...
...

References

SHOWING 1-10 OF 60 REFERENCES
lncRNA-HIT promotes cell proliferation of non-small cell lung cancer by association with E2F1
TLDR
It is indicated that lncRNA-HIT affected the proliferation of NSCLC cells at least in part via regulating the occupancy of E2F1 in the promoter regions of its target genes.
LncRNA-RMRP Acts as an Oncogene in Lung Cancer
TLDR
It is proved that RMRP acted as an oncogene LncRNA to promote the expression of KRAS, FMNL2 and SOX9 by inhibiting miR-206 expression in lung cancer and suggested that R MRP might serve as a therapeutic target in lung adenocarcinoma.
LncRNA MALAT1 Depressed Chemo-Sensitivity of NSCLC Cells through Directly Functioning on miR-197-3p/p120 Catenin Axis
TLDR
MALAT1 could alter chemo-resistance of NSCLC cells by targeting miR-197-3p and regulating p120-ctn expression, which might assist in improvement ofChemo-therapies forNSCLC.
LINC00210 as a miR-328-5p sponge promotes nasopharyngeal carcinoma tumorigenesis by activating NOTCH3 pathway
TLDR
It is revealed that LINC00210 contributed to NPC cell proliferation and invasion in vitro, and promotes tumor growth in vivo, and miR-328-5p targets the 3′ untranslated region (3′-UTR) of NOTCH3.
The effects of aberrant expression of LncRNA DGCR5/miR‐873‐5p/TUSC3 in lung cancer cell progression
TLDR
The role of DGCR5 in tumorigenesis in vivo was consistent with in vitro assays, Ki‐67‐positive cell number (exhibited by immunohistochemical staining), tumor size, and tumor weight of A549‐DGCR5 group were significantly lower in comparison with A549•control group.
Long non-coding RNA DGCR5 is involved in the regulation of proliferation, migration and invasion of lung cancer by targeting miR-1180.
TLDR
DGCR5 was downregulated and miR-1180 was upregulated in the sera and tissues of LC patients and was correlated with poor prognosis, suggesting that DGCR5 might serve as a potential target for the development of effective anti-neoplastic therapies in lung cancer.
miR-328-5p inhibits MDA-MB-231 breast cancer cell proliferation by targeting RAGE.
TLDR
Results revealed that miR-328-5p may be considered as a tumour-suppressor factor, and promoting miR+5p expression could be a novel therapeutic strategy for breast cancer.
Long non-coding RNA TPTEP1 inhibits hepatocellular carcinoma progression by suppressing STAT3 phosphorylation
TLDR
A tumor suppressing role of TPTEP1 in HCC progression is suggested and a novel understanding of T PTEP1 during the chemotherapy for HCC is provided.
SP1‐mediated overexpression of lncRNA LINC01234 as a ceRNA facilitates non‐small‐cell lung cancer progression via regulating OTUB1
TLDR
In vitro assays showed that inhibition of LINC01234 suppressed NSCLC cell proliferation, cell colony formation and metastasis, and greatly promoted apoptosis, and Mechanistic investigations revealed LINC 01234 promotes the progression of NSCLCs cells by the modulation of miR‐140 to positively regulate OTUB1 expression.
...
...