Corpus ID: 208956798

lncRNA PCAT-1 interacting with FZD6 contributes to the malignancy of acute myeloid leukemia cells through activating Wnt/β-catenin signaling pathway.

@article{Yuan2019lncRNAPI,
  title={lncRNA PCAT-1 interacting with FZD6 contributes to the malignancy of acute myeloid leukemia cells through activating Wnt/β-catenin signaling pathway.},
  author={Y. Yuan and Q. Wang and S. Ma and L. Xu and Meng Liu and B. Han and N. Du and Xiao Sun and X. Yin and F. Cao},
  journal={American journal of translational research},
  year={2019},
  volume={11 11},
  pages={
          7104-7114
        }
}
  • Y. Yuan, Q. Wang, +7 authors F. Cao
  • Published 2019
  • Biology, Medicine
  • American journal of translational research
Accumulating evidence has suggested the involvement of long noncoding RNAs (lncRNAs) on the acute myeloid leukemia (AML). Therefore, this study aimed to investigate the unknown function of lncRNA Prostate cancer-associated transcript-1 (PCAT-1) in AML cells. Our data found that PCAT-1 was highly expressed in AML-M1/2 and AML-M3 patients than normal controls and its expression was significantly up-regulated in AML cell lines Kasumi-6 and HL-60. The functional experiments demonstrated that… Expand
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