• Corpus ID: 116077146

liver cells : Implications for structure activity relationship Cytotoxic and antioxidant effects of methoxylated stilbene analogues on HepG 2 hepatoma and Chang

@inproceedings{Hasiah2011liverC,
  title={liver cells : Implications for structure activity relationship Cytotoxic and antioxidant effects of methoxylated stilbene analogues on HepG 2 hepatoma and Chang},
  author={A H Hasiah and A R Ghazali and J F F Weber and S. Velu and N F Thomas and Shabir Hussain},
  year={2011}
}

• A. Hasiah, A. Ghazali, +3 authors S. Hussain
• Published 2011
• Chemistry, Biology

Stilbenes possess a variety of biological activities including chemopreventive activity. This study was conducted to evaluate the structural activity relationships of six methoxylated stilbene analogues with respect to their cytotoxic effects and antioxidant activities on HepG2 hepatoma and Chang liver cells. The cytotoxic and total antioxidant activities of six stilbene analogues were determined by MTT and Ferric Reducing Antioxidant Power (FRAP) assays, respectively. We found that the cis-methoxylated stilbene: (Z)-3,4,40-trimethoxystilbene was the most potent and selective antiproliferative agent (IC50 89 mM) in HepG2 cells. For the total antioxidant activity, compounds possessing hydroxyl groups at the 40 position namely (E)-3-methoxy-40-hydroxystilbene, (E)-3,5-dimethoxy-40-hydroxystilbene (pterostilbene), (E)-4-methoxy-40-hydroxystilbene showed the highest antioxidant activity. Structure activity relationship studies of these compounds demonstrated that the cytotoxic effect and antioxidant activities of the tested compounds in this study were structurally dependent.