• Corpus ID: 245836890

life$^x$ - heart module: a high-performance simulator for the cardiac function. Package 1: Fiber generation

  title={life\$^x\$ - heart module: a high-performance simulator for the cardiac function. Package 1: Fiber generation},
  author={Pasquale Claudio Africa and Roberto Piersanti and Marco Fedele and Luca Dede’ and Alfio Quarteroni},
Modeling the whole cardiac function involves several complex multiphysics and multi-scale phenomena that are highly computationally demanding, which makes calling for simpler yet accurate, high-performance computational tools still a paramount challenge to be addressed. Despite all the efforts made by several research groups worldwide, no software has progressed as a standard reference tool for whole-heart fully-coupled cardiac simulations in the scientific community yet. In this work we… 

Figures from this paper

Lifex: a Flexible, High Performance Library for the Numerical Solution of Complex Finite Element Problems

This document introduces the design and the capabilities of life x, an open source C++ library for high performance element simulations of multiphysics, multiscale and multidomain problems, and shows its parallel performance up to thousands of cores.

A mathematical model that integrates cardiac electrophysiology, mechanics and fluid dynamics: application to the human left heart

We propose a mathematical and numerical model for the simulation of the heart function that couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and includes reduced

A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

The proposed model represents the state-of-the-art electromechanical model of the iHEART ERC project – an Integrated Heart Model for the Simulation of the Cardiac Function – and is a fundamental step toward the building of physics-based digital twins of the human heart.

A comparative study of scalable multilevel preconditioners for cardiac mechanics

In this work, we provide a performance comparison between the Balancing Domain Decomposition by Constraints (BDDC) and the Algebraic Multigrid (AMG) preconditioners for cardiac mechanics on both

A geometric multiscale model for the numerical simulation of blood flow in the human left heart

We present a new computational model for the numerical simulation of blood flow in the human left heart. To this aim, we use the Navier-Stokes equations in an Arbitrary Lagrangian Eulerian

A reduced order model for domain decompositions with non-conforming interfaces

A reduced order modeling strategy for two-way Dirichlet-Neumann parametric coupled problems solved with domain-decomposition (DD) sub-structuring methods that is numerically verified on both steady and unsteady coupled problems, in the case of non-conforming FE interfaces.



A publicly available virtual cohort of four-chamber heart meshes for cardiac electro-mechanics simulations

This work has created the first publicly available virtual cohort of twenty-four four-chamber hearts, built from heart failure patients, to facilitate large cohort computational studies and to promote the development of cardiac computational electro-mechanics for clinical applications.

Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations

Modeling the cardiac response to hemodynamic changes associated with COVID-19: a computational study.

A computational model is proposed to effectively reveal the interactions between the cardiac and pulmonary functions in virtual subjects with normal and impaired cardiac function at baseline affected by mild or severe COVID-19.

A cardiac electromechanics model coupled with a lumped parameters model for closed-loop blood circulation. Part II: numerical approximation

A numerical method to couple the 3D electromechanical model and the 0D circulation model in a numerically stable manner within a fully segregated fashion and shows the convergence property of the numerical schemes by performing an accuracy study through grid refinement.

A multiscale CFD model of blood flow in the human left heart coupled with a lumped-parameter model of the cardiovascular system

The Navier-Stokes equations in an Arbitrary Lagrangian Eulerian formulation are employed to account for the endocardium motion, and the model of both the mitral and the aortic valves is model by means of the Resistive Immersed Implicit Surface method.

A rule‐based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts

A modeling pipeline for creating patient‐specific volumetric meshes of biventricular geometries, including the outflow tracts, is built and its potential for an in silico identification of the site of origin in outflow tract ventricular arrhythmias before clinical intervention is confirmed.