let-7 miRNAs Can Act through Notch to Regulate Human Gliogenesis

  title={let-7 miRNAs Can Act through Notch to Regulate Human Gliogenesis},
  author={Malcolm Patterson and Xavier Gaeta and Kyi Kyi Loo and Martin P Edwards and Steve Smale and Jessica K Cinkornpumin and Yubin Xie and Jennifer Listgarten and Soheila F. Azghadi and S. M. Douglass and Massimo Pellegrini and William E Lowry},
  booktitle={Stem cell reports},
It is clear that neural differentiation from human pluripotent stem cells generates cells that are developmentally immature. Here, we show that the let-7 plays a functional role in the developmental decision making of human neural progenitors, controlling whether these cells make neurons or glia. Through gain- and loss-of-function studies on both tissue and pluripotent derived cells, our data show that let-7 specifically regulates decision making in this context by regulation of a key chromatin… CONTINUE READING

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