legless insertional mutation: morphological, molecular, and genetic characterization.

  title={legless insertional mutation: morphological, molecular, and genetic characterization.},
  author={Guramrit Singh and Dorothy M Supp and Cristina Schreiner and J Mcneish and H. J. Merker and Neal G. Copeland and Nancy A. Jenkins and S. Steven Potter and William Scott},
  journal={Genes & development},
  volume={5 12A},
Limb morphogenesis is an excellent model system to study pattern formation during vertebrate development. The legless (lgl) insertional mutation can serve as a tool to analyze specific events in limb development at the embryologic, genetic, and molecular levels. Hemizygous mice of this transgenic line are phenotypically normal, but homozygous mutants are inviable and exhibit limb, brain, and craniofacial malformations, as well as situs inversus. By morphological analysis of mutant hindlimb buds… CONTINUE READING
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