lac repressor: crystallization of intact tetramer and its complexes with inducer and operator DNA.

@article{Pace1990lacRC,
  title={lac repressor: crystallization of intact tetramer and its complexes with inducer and operator DNA.},
  author={Helen C. Pace and Ponzy Lu and Mitchell Lewis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 5},
  pages={1870-3}
}
The intact lac repressor tetramer, which regulates expression of the lac operon in Escherichia coli, has been crystallized in the native form, with an inducer, and in a ternary complex with operator DNA and an anti-inducer. The crystals without DNA diffract to better than 3.5 A. They belong to the monoclinic space group C2 and have cell dimensions a = 164.7 A, b = 75.6 A, and c = 161.2 A, with alpha = gamma = 90 degrees and beta = 125.5 degrees. Cocrystals have been obtained with a number of… CONTINUE READING